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A cadherin mutation in <i>Celsr3</i> linked to Tourette Disorder affects dendritic patterning and excitability of cholinergic interneurons

2022-03-07

Abstract excerpt

CELSR3 encodes an atypical protocadherin cell adhesion receptor that was recently identified as a high-risk gene for Tourette disorder. A putative damaging de novo variant was inserted into the mouse genome to generate an amino acid substitution within the fifth cadherin repeat. By contrast to Celsr3 constitutive null animals, mice homozygous for the R774H amino acid substitution are viable and have grossly norm...

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Literature Corpus work
18ea2590-8a8c-5f02-84c1-64cba2d1d548
DOI
10.1101/2022.03.06.483205
Open publication

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A cadherin mutation in <i>Celsr3</i> linked to Tourette Disorder affects dendritic patterning and excitability of cholinergic interneuronsDOI 10.1101/2022.03.06.483205
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