Article
Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice.
Cell reports. Medicine - 21 May 2024
Guo Baolin, Liu Tiaotiao, Choi Soonwook, Mao Honghui, Wang Wenting, Xi Kaiwen, Jones Carter, Hartley Nolan D, Feng Dayun, Chen Qian, Liu Yingying, Wimmer Ralf D, Xie Yuqiao, Zhao Ningxia, Ou Jianjun, Arias-Garcia Mario A, Malhotra Diya, Liu Yang, Lee Sihak, Pasqualoni Sammuel, Kast Ryan J, Fleishman Morgan, Halassa Michael M, Wu Shengxi, Fu Zhanyan
Abstract excerpt
Thalamocortical (TC) circuits are essential for sensory information processing. Clinical and preclinical studies of autism spectrum disorders (ASDs) have highlighted abnormal thalamic development and TC circuit dysfunction. However, mechanistic understanding of how TC dysfunction contributes to behavioral abnormalities in ASDs is limited. Here, our study on a Shank3 mouse model of ASD reveals TC neuron...
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