Article

<i>Cntnap2</i> loss drives striatal neuron hyperexcitability and behavioral inflexibility

2024-05-09

Abstract excerpt

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by two major diagnostic criteria – persistent deficits in social communication and interaction, and the presence of restricted, repetitive patterns of behavior (RRBs). Evidence from both human and animal model studies of ASD suggest that alteration of striatal circuits, which mediate motor learning, action selection, and habit formation,...

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Literature Corpus work: 52f5708c-c047-510e-bb9d-c411641cda38
DOI: 10.1101/2024.05.09.593387

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