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Article

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning.

Cell reports - 10 Aug 2021

Benthall Katelyn N, Cording Katherine R, Agopyan-Miu Alexander H C W, Wong Corinna D, Chen Emily Y, Bateup Helen S

Abstract excerpt

Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder that often presents with psychiatric conditions, including autism spectrum disorder (ASD). ASD is characterized by restricted, repetitive, and inflexible behaviors, which may result from abnormal activity in striatal circuits that mediate motor learning and action selection. To test whether altered striatal activity contributes to aberrant motor...

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Identifiers

PMID: 34380034
DOI: 10.1016/j.celrep.2021.109511
PMCID: PMC8404511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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