Article

Approximate Bayesian computation supports a high incidence of chromosomal mosaicism in blastocyst-stage human embryos

2024-12-02

Abstract excerpt

Chromosome mis-segregation is common in human meiosis and mitosis, and the resulting aneuploidies are the leading cause of pregnancy loss. Preimplantation genetic testing for aneuploidy (PGT-A) prioritizes chromosomally normal embryos for transfer based on analysis of a biopsy of approximately five trophectoderm cells from blastocyst-stage in vitro fertilized (IVF) embryos. While modern PGT-A platforms classify t...

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Literature Corpus work: 5de66283-3a42-54cc-ae4f-ccccd6c883b2
DOI: 10.1101/2024.11.26.625484

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