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Identifying parental and cell-division origins of aneuploidy in the human blastocyst

27 Mar 2023

Abstract excerpt

Preimplantation genetic testing commonly employs simplistic copy-number analyses to screen for aneuploidy in blastocyst trophectoderm biopsies. Interpreting intermediate copy number alone as evidence of mosaicism has led to suboptimal estimation of its prevalence. Because mosaicism originates from mitotic nondisjunction, utilizing SNP microarray technology to identify the cell-division origins of aneuploidy might...

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Assisted Reproductive Technology and Twin Pregnancy
Genomic variations and chromosomal abnormalities
Prenatal Screening and Diagnostics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36977411
DOI: 10.1016/j.ajhg.2023.03.003

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