Article

Machine learning can identify orphans that have diverged into the “twilight zone” of sequence similarity

2025-06-08

Abstract excerpt

Species-specific orphan genes (orphans) lack homologues outside of a given taxon and frequently underlie unique species traits. It is thus important to elucidate the evolutionary origins of orphans. Orphan genes can result from sequence divergence beyond recognition, when homologous proteins diverge to an extent at which tools that rely on sequence similarity to establish homology can no longer identify them as ho...

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Literature Corpus work: 5dd9ba0c-90da-5e1f-b83a-dbd430031016
DOI: 10.1101/2025.06.06.658213

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