Article

Identification and Classification of Expressed Orphan Genes, Spurious Orphan Genes, and Conserved Genes in the Human Gut Microbiome

2026-01-17

Abstract excerpt

Orphan genes - genes lacking detectable homologs outside a species - are widespread in microbial genomes and are thought to contribute to their adaptation and molecular innovation. However, not all predicted orphan genes may represent novel functional coding sequences. False positive orphan genes, also called spurious orphan genes, can arise from gene prediction errors. We reason that orphan genes lacking detectab...

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Literature Corpus work: efd1986e-d877-55d9-adbd-436ca27efb42
DOI: 10.64898/2026.01.16.699869

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