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Article

WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning.

PLoS computational biology - 1 Nov 2016

Sutphin George L, Mahoney J Matthew, Sheppard Keith, Walton David O, Korstanje Ron

Abstract excerpt

The rapid advancement of technology in genomics and targeted genetic manipulation has made comparative biology an increasingly prominent strategy to model human disease processes. Predicting orthology relationships between species is a vital component of comparative biology. Dozens of strategies for predicting orthologs have been developed using combinations of gene and protein sequence, phylogenetic history, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27812085
DOI: 10.1371/journal.pcbi.1005182
PMCID: PMC5094675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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