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Unpacking circulating tumor DNA lends insight into prostate cancer biology and the clonal dynamics of metastasis.

Cancer cell - 10 Oct 2022

Takeda David Y, Sowalsky Adam G

Abstract excerpt

Prostate cancer (PCa) frequently metastasizes to bone, and analyses of DNA from bone biopsies are exceptionally challenging. A recent report in Nature demonstrates that whole-genome sequencing (WGS) of circulating tumor DNA (ctDNA) from patients with metastatic PCa can inform on the subclonal composition of metastatic disease and infer patterns of gene expression.

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Identifiers

PMID: 36179684
DOI: 10.1016/j.ccell.2022.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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