Article

Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs with Trisomy 21

2021-10-19

Abstract excerpt

<h4>Summary</h4> The intellectual disability found in people with Down syndrome (DS) is associated with a decrease in white matter in the central nervous system. To study the mechanism of this myelination deficit, we differentiated two isogenic lines of induced pluripotent stem cells (iPSCs) derived from people with DS into brain-like and spinal cord-like neural progenitor cells (NPCs) and promoted a transition t...

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Literature Corpus work: 5daf63d6-4adf-52e9-ac4a-00f09cdc413c
DOI: 10.1101/2021.10.19.465029

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