Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21

4 Jan 2022

Abstract excerpt

The intellectual disability found in people with Down syndrome is associated with numerous changes in early brain development, including the proliferation and differentiation of neural progenitor cells (NPCs) and the formation and maintenance of myelin in the brain. To study how early neural precursors are affected by trisomy 21, we differentiated two isogenic lines of induced pluripotent stem cells derived from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Hedgehog Signaling Pathway Studies
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35058753
DOI: 10.3389/fncel.2021.794675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21PMID 35058753Read ↗

Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs with Trisomy 21Semantic proximity Read ↗

Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndromeSemantic proximity Read ↗

A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome.Semantic proximity Read ↗

Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome BrainSemantic proximity Read ↗

Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling.Semantic proximity Read ↗

OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitorsSemantic proximity Read ↗

Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain developmentSemantic proximity Read ↗

Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21Semantic proximity Read ↗

Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21Semantic proximity Read ↗

Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation.Semantic proximity Read ↗

Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brainSemantic proximity Read ↗

Transcriptional consequences of trisomy 21 on neural inductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.