Article

Accelerated Tempo of Cortical Neurogenesis in Down Syndrome

2025-09-30

Abstract excerpt

<h4>Summary</h4> Down syndrome (DS), caused by trisomy 21 (TS21), is the most common genetic cause of intellectual disability 1,2 . The neurological impacts of DS first manifest during prenatal development through reduced radial glia (RG) neural stem cell proliferation, reduced cortical volume and imbalanced cortical cell types 3–6 . However, the developmental mechanisms underlying altered cortical neurogenesis...

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Literature Corpus work: e3dad32e-c494-5994-be75-92c4302dc4ef
DOI: 10.1101/2025.09.29.679346

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