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Article

OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors

17 Feb 2012

Abstract excerpt

Mental retardation and early Alzheimer's disease (AD) have generally been attributed to progressive neuronal loss in the developing and mature Down syndrome (DS) brain. However, reduced neuronal production during development could also contribute to the smaller brain size and simplified gyral patterning seen in this disorder. Here, we show impairments in proliferation within the ventricular zone (VZ) of early DS...

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PMID: 22343408
DOI: 10.1093/hmg/dds052

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