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Article

Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation.

Stem cell reports - 11 Oct 2016

Halevy Tomer, Biancotti Juan-Carlos, Yanuka Ofra, Golan-Lev Tamar, Benvenisty Nissim

Abstract excerpt

Down syndrome (DS) is the leading genetic cause of mental retardation and is caused by a third copy of human chromosome 21. The different pathologies of DS involve many tissues with a distinct array of neural phenotypes. Here we characterize embryonic stem cell lines with DS (DS-ESCs), and focus on the neural aspects of the disease. Our results show that neural progenitor cells (NPCs) differentiated from five...

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Source

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Identifiers

PMID: 27618722
DOI: 10.1016/j.stemcr.2016.08.003
PMCID: PMC5063584

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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