OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

Abstract excerpt

<h4>SUMMARY</h4> Down syndrome (DS) is a common neurodevelopmental disorder, and cognitive defects in DS patients may arise form imbalances in excitatory and inhibitory neurotransmission. Understanding the mechanisms underlying such imbalances may provide opportunities for therapeutic intervention. Here, we show that human induced pluripotent stem cells (hiPSCs) derived from DS patients overproduce OLIG2 + ventr...

Topics

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• Autistic Disorder
• Chromatin Assembly and Disassembly
• Congenital heart defects research
• Down syndrome and intellectual disability research
• Genetics and Neurodevelopmental Disorders
• Histone Code
• Induced Pluripotent Stem Cells
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

66235c6e-aded-54a5-a53e-ad9bac717228

DOI

10.1101/462739