Article

The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells

2024-03-04

Abstract excerpt

Marginal zone (MZ) B cells bridge innate and adaptive immunity by sensing bloodborne antigens and producing rapid antibody and cytokine responses. CD55 is a membrane-bound complement regulator that interferes with complement activation, an important component of innate immunity. CD55 also regulates adaptive immunity—CD55 downregulation is critical for germinal center reactions. MZ B cells also express low CD55, bu...

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Literature Corpus work: 5da04f29-6ae9-5f1c-a8c5-5406516784fe
DOI: 10.1101/2024.03.01.582833

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