Article
Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2006
Won Woong-Jai, Foote Jeremy B, Odom Mary R, Pan Jicun, Kearney John F, Davis Randall S
Abstract excerpt
Two members of the recently identified FcR homolog (FcRH) family in mice demonstrate preferential B cell expression. One of these, FcRH3, encodes a type I transmembrane protein with five extracellular Ig domains and a cytoplasmic tail with a consensus ITIM and a noncanonical ITAM. Analysis of full-length cDNAs from five different mouse strains defines two FcRH3 alleles. A panel of FcRH3-specific mAbs was...
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