Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immature recent thymic emigrants are eliminated by complement.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014

Hsu Fan-Chi, Shapiro Michael J, Chen Meibo W, McWilliams Douglas C, Seaburg Lauren M, Tangen Sarah N, Shapiro Virginia Smith

Abstract excerpt

Recent thymic emigrants (RTEs) must undergo phenotypic and functional maturation to become long-lived mature naive T cells. In CD4-cre NKAP conditional knockout mice, NKAP-deficient RTEs fail to complete T cell maturation. In this study, we demonstrate that NKAP-deficient immature RTEs do not undergo apoptosis, but are eliminated by complement. C3, C4, and C1q are bound to NKAP-deficient peripheral T cells,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, B-Lymphocyte
Share to CD55 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Activation

Share to Complement C3

Share to Complement System Proteins

Share to Immunoglobulin M

Share to Leukocyte Common Antigens

Share to N-Acetylneuraminic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 25367120
DOI: 10.4049/jimmunol.1401871
PMCID: PMC4332405

Genes

NKAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immature recent thymic emigrants are eliminated by complement.PMID 25367120Read ↗

Recent thymic emigrants produce antimicrobial IL-8, express complement receptors and are precursors of a tissue-homing Th8 lineage of memory cellsSemantic proximity Read ↗

TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells.Semantic proximity Read ↗

The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cellsSemantic proximity Read ↗

B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase.Semantic proximity Read ↗

SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics.Semantic proximity Read ↗

B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanismSemantic proximity Read ↗

B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS.Semantic proximity Read ↗

Thymic Nurse Cells Participate in Heterotypic Internalization and Repertoire Selection of Immature Thymocytes; Their Removal from the Thymus of Autoimmune Animals May be Important to Disease Etiology.Semantic proximity Read ↗

Maturation and emigration of single-positive thymocytes.Semantic proximity Read ↗

Frontline Science: A hyporesponsive subset of rat NK cells negative for Ly49s3 and NKR-P1B are precursors to the functionally mature NKR-P1B+ subset.Semantic proximity Read ↗

Human NK cell development requires CD56-mediated motility and formation of the developmental synapseSemantic proximity Read ↗

Recent thymic emigrants are distinct from most medullary thymocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.