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Article

Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility.

Immunity - 1 Feb 2003

Qin Xuebin, Krumrei Nicole, Grubissich Luciano, Dobarro Martin, Aktas Huseyin, Perez Graciela, Halperin Jose A

Abstract excerpt

Basal complement activity presents a potential danger for "self" cells that are tightly protected by complement regulators including CD59. Mice express two Cd59 genes (mCd59a and mCd59b); mCd59b has approximately a 6-fold higher specific activity than mCd59a. Consistently, mCd59b knockout mice present a strong phenotype characterized by hemolytic anemia with increased reticulocytes, anisopoikilocytosis,...

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Identifiers

PMID: 12594949
DOI: 10.1016/s1074-7613(03)00022-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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