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Article

Huntington's disease and Group I metabotropic glutamate receptors.

Molecular neurobiology - 1 Feb 2011

Ribeiro Fabiola M, Pires Rita G W, Ferguson Stephen S G

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary body movement, cognitive impairment and psychiatric disturbance. A polyglutamine expansion in the amino-terminal region of the huntingtin (htt) protein is the genetic cause of HD. Htt protein interacts with a wide variety of proteins, and htt mutation causes cell signaling alterations in various...

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PMID: 21153060
DOI: 10.1007/s12035-010-8153-1

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