Pathophysiology of Huntingtonʼs disease: from huntingtin functions to potential treatments

Abstract excerpt

PURPOSE OF REVIEW: Drugs used to treat Huntington's disease act on the symptoms but do not slow the disease process itself. This review focuses on recent pathogenetic findings and on emerging therapeutic approaches. RECENT FINDINGS: Basic research is providing novel insights into the complex molecular pathways involved in the pathogenesis of Huntington's disease. Several mechanisms have been identified that...

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