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Article

Mechanisms of neurodegeneration in Huntington's disease.

The European journal of neuroscience - 1 Jun 2008

Gil Joana M, Rego Ana Cristina

Abstract excerpt

Huntington's disease (HD) is caused by an expansion of cytosine-adenine-guanine (CAG) repeats in the huntingtin gene, which leads to neuronal loss in the striatum and cortex and to the appearance of neuronal intranuclear inclusions of mutant huntingtin. Huntingtin plays a role in protein trafficking, vesicle transport, postsynaptic signaling, transcriptional regulation, and apoptosis. Thus, a loss of function of...

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Identifiers

PMID: 18588526
DOI: 10.1111/j.1460-9568.2008.06310.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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