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A Critical Evaluation of Adenosine A2A Receptors as Potentially &#x201C;Druggable&#x201D; Targets in Huntingtons Disease

1 May 2008

Abstract excerpt

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by the expansion of a polymorphic CAG trinucleotide repeat encoding a poly-glutamine tract within the Huntingtin protein. GABAergic enkephalin neurons of the basal ganglia, which show the highest levels of expression of adenosine A(2A) receptors, are the most vulnerable in HD. Such a selective neuronal vulnerability, which...

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PMID: 18537673
DOI: 10.2174/138161208784480117

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