Article

Sex differences in transcription-associated mutagenesis in the human germline

2025-09-20

Abstract excerpt

In humans, germline mutation rates are three- to four-fold higher in males than females, for largely unknown reasons. We investigated whether transcription, a well-documented source of both DNA damage and repair in somatic tissues, is associated with sex differences in germline mutations. To this end, we used expression data from male and female germline cells and phased de novo germline mutations from pedigrees....

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Identifiers and source

Literature Corpus work: d5190b7d-0977-5cfc-8742-901f51574082
DOI: 10.1101/2025.09.18.677082

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