Article

Single-cell mtDNA heteroplasmy in colorectal cancer

2021-11-28

Abstract excerpt

Human mitochondria can be genetically distinct within the same individual, a phenomenon known as heteroplasmy. In cancer, this phenomenon seems exacerbated, and most mitochondrial mutations seem to be heteroplasmic. How this genetic variation is arranged within and among normal and tumor cells is not well understood. To address this question, here we sequenced single-cell mitochondrial genomes from multiple normal...

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Literature Corpus work: 5d8caa32-2790-528a-bc43-5f69dec8e944
DOI: 10.1101/2021.11.24.21266805

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