Article
Somatic mutations of the mitochondrial genome in human colorectal tumours.
Nature genetics - 1 Nov 1998
Polyak K, Li Y, Zhu H, Lengauer C, Willson J K, Markowitz S D, Trush M A, Kinzler K W, Vogelstein B
Abstract excerpt
Alterations of oxidative phosphorylation in tumour cells were originally believed to have a causative role in cancerous growth. More recently, mitochondria have again received attention with regards to neoplasia, largely because of their role in apoptosis and other aspects of tumour biology. The mitochondrial genome is particularly susceptible to mutations because of the high level of reactive oxygen species...
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