Somatic mutations of the mitochondrial genome in human colorectal tumours.

doi:10.1038/3108

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Article

Somatic mutations of the mitochondrial genome in human colorectal tumours.

Nature genetics - 1 Nov 1998

Polyak K, Li Y, Zhu H, Lengauer C, Willson J K, Markowitz S D, Trush M A, Kinzler K W, Vogelstein B

Abstract excerpt

Alterations of oxidative phosphorylation in tumour cells were originally believed to have a causative role in cancerous growth. More recently, mitochondria have again received attention with regards to neoplasia, largely because of their role in apoptosis and other aspects of tumour biology. The...

Topics

Base Sequence
Cell Fusion
Colorectal Neoplasms
DNA Damage
DNA, Mitochondrial
DNA, Neoplasm
Genome, Human
Humans
Mutation
Reactive Oxygen Species
Tumor Cells, Cultured

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