Article
Cancer-specific SNPs originate from low-level heteroplasmic variants in human mitochondrial genomes of a matched cell line pair.
Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis - 1 Jan 2019
Hedberg Annica, Knutsen Erik, Løvhaugen Anne Silje, Jørgensen Tor Erik, Perander Maria, Johansen Steinar D
Abstract excerpt
Low-level mitochondrial heteroplasmy is a common phenomenon in both normal and cancer cells. Here, we investigate the link between low-level heteroplasmy and mitogenome mutations in a human breast cancer matched cell line by high-throughput sequencing. We identified 23 heteroplasmic sites, of which 15 were common between normal cells (Hs578Bst) and cancer cells (Hs578T). Most sites were clustered within the...
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