Article

Genetic contribution to asthma informs acute chest syndrome pathophysiology and risk stratification

2025-10-02

Abstract excerpt

Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD), but we lack tool to identify patients at high risk of ACS. Epidemiological studies have found an association between asthma and ACS but whether this link is causal is unclear. We used polygenic score (PGS) to analyze whether the genetic susceptibility to asthma was associated with ACS and could be used to stratify the risk of ACS. We...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d874802-9c0f-5dc3-a89b-1b0dca8dc519
DOI: 10.1101/2025.09.30.25336662

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic contribution to asthma informs acute chest syndrome pathophysiology and risk stratificationDOI 10.1101/2025.09.30.25336662Read

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification.Semantic proximity Read

Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma.Semantic proximity Read

Cumulative Genetic Risk for Asthma Contributes to Disease Severity in Children with AsthmaSemantic proximity Read

Revealing polygenic pleiotropy using genetic risk scores for asthmaSemantic proximity Read

Highlighting the importance of healthy sleep patterns in the risk of adult asthma under the combined effects of genetic susceptibility: a large-scale prospective cohort study of 455 405 participants.Semantic proximity Read

Variation and impact of polygenic hematological traits in monogenic sickle cell diseaseSemantic proximity Read

A polygenic risk score for asthma in a large racially diverse population.Semantic proximity Read

Variation and impact of polygenic hematologic traits in monogenic sickle cell disease.Semantic proximity Read

Biomarkers for the diagnosis and phenotyping of acute chest syndrome in patients with sickle cell disease.Semantic proximity Read

Epigenomic partitioning of a polygenic risk score for asthma reveals distinct genetically driven disease pathways.Semantic proximity Read

Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients.Semantic proximity Read

Identifying rare variants for genetic risk through a combined pedigree and phenotype approach: application to suicide and asthma.Semantic proximity Read