Article
Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification.
American journal of hematology - 1 May 2026
El Aouhel Sara, Bellegarde Vanessa, Da Silva Faria Stennio, St-Laurent Tristan, Lecluze Estelle, Pham Hung d'Alexandry d'Orengiani Anne-Laure, Galactéros Frédéric, Bartolucci Pablo, Legault Marc-André, Lettre Guillaume, Pincez Thomas
Abstract excerpt
Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is unclear. We used polygenic scores (PGS) to analyze whether the genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.