Article
Variation and impact of polygenic hematological traits in monogenic sickle cell disease
2022-01-27
Abstract excerpt
<h4>ABSTRACT</h4> Several complications observed in sickle cell disease (SCD) are influenced by variation in hematological traits (HT), such as fetal hemoglobin (HbF) level and neutrophil count. Previous large-scale genome-wide association studies carried out in largely healthy individuals have identified 1000s of variants associated with HT, which have then been used to develop multi-ancestry polygenic trait scor...
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Identifiers and source
- Literature Corpus work
- e5f7f36d-46d8-567f-9036-111ccbf37caa
- DOI
- 10.1101/2022.01.26.22269309