Article
Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma.
American journal of human biology : the official journal of the Human Biology Council - 1 Jan 2000
Phillips Keydra L, An Ping, Boyd Jessica H, Strunk Robert C, Casella James F, Barton Bruce A, DeBaun Michael R
Abstract excerpt
In the United States, sickle cell anemia (SCA) affects approximately 1 in 400 African-American newborns. Acute episodes of pain and acute chest syndrome (ACS) are the two leading causes of hospitalization. A relationship between the diagnosis of asthma and the incidence of pain and ACS has been established. We tested the hypothesis that a familial pattern of inheritance of asthma exists among first degree...
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