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Article

Cellular Atlas of Senescent Lineages in Radiation- or Immunotherapy-Induced Lung Injury by Single-Cell RNA-Sequencing Analysis

13 Feb 2023

Abstract excerpt

PURPOSE: Although the combination of immunotherapy and radiation therapy to treat various malignancies is rapidly expanding, concerns regarding increased pulmonary toxicities remain. The mechanisms of immunotherapy- and irradiation-induced lung injury involve a complex interplay of cell types and signaling pathways, much of which remains to be elucidated. METHODS AND MATERIALS: C57/BL6 mice were treated with a...

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PMID: 36792015
DOI: 10.1016/j.ijrobp.2023.02.005

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