Article

Systematic transcriptomic analysis and temporal modelling of the senescent human fibroblast

2022-08-17

Abstract excerpt

Cellular senescence is a diverse phenotype characterised by permanent cell cycle arrest and an inflammatory senescence associated secretory phenotype (SASP). Typically, senescent cells are removed by the immune system. This process becomes dysregulated with age and senescent cells accumulate leading to chronic inflammatory signalling. Identifying senescent cells is challenging due to the heterogeneity of senescenc...

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Literature Corpus work: 1435b0f9-a158-51e1-b1ca-2c7327ec9004
DOI: 10.1101/2022.08.16.504144

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