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Cellular senescence dysregulates antiviral interferon responses in idiopathic pulmonary fibrosis

2026-04-23

Abstract excerpt

<h4>ABSTRACT</h4> Patients with idiopathic pulmonary fibrosis (IPF) are highly vulnerable to respiratory virus infections, but the cellular mechanisms linking fibrotic remodeling to impaired local antiviral defense remain unclear. Here, we investigated how cellular senescence shapes the response of patient-derived healthy and IPF primary lung fibroblasts to influenza A virus (IAV) infection. Transcriptomic profil...

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Literature Corpus work
25ac6fca-5459-5fb6-8a37-802186a1b503
DOI
10.64898/2026.04.20.719739
Open publication

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Cellular senescence dysregulates antiviral interferon responses in idiopathic pulmonary fibrosisDOI 10.64898/2026.04.20.719739
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