Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein

Abstract excerpt

Neuropathologic and genetics studies as well as transgenic animal models have provided strong evidence linking misfolding and aggregation of alpha-synuclein to the progression of Parkinson disease (PD) and other related disorders. A growing body of evidence implicates various oligomeric forms of alpha-synuclein as the toxic species responsible for neurodegeneration and neuronal cell death. Although numerous...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Nerve injury and regeneration
• Share to Neurological disorders and treatments
• Share to Parkinson's Disease Mechanisms and Treatments