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Article

Immune Cytolytic Activity Correlates with Tumor Microenvironmental Aberrations in Colorectal Cancer.

International journal of molecular sciences - 10 Jul 2026

Agioti Stephanie, Georgoulias George, Georgakopoulos-Soares Ilias, Christodoulou Maria-Ioanna, Zaravinos Apostolos

Abstract excerpt

Colorectal cancer (CRC) exhibits a highly heterogeneous tumor immune microenvironment (TME), ranging from "immune-inflamed" to "immune-desert" or "immune-excluded" phenotypes. Understanding how immune cell composition, cytolytic activity (CYT) and genomic alternations shape tumor-immune interactions is critical for improving immunotherapy outcomes. We analyzed TCGA-COAD and TCGA-READ datasets to evaluate immune...

Read the complete abstract on PubMed

Topics

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Share to Colorectal Neoplasms
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to CXCL9 gene

Share to Gene Expression Regulation, Neoplastic

Share to Microsatellite Instability

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Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 42511524
DOI: 10.3390/ijms27146180
PMCID: PMC13409973

Genes

C1QA
CXCL13
CXCL9
GZMA
IDO1
PRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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