Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study.

doi:10.1016/S1470-2045(22)00783-5

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Article

Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study.

The Lancet. Oncology - 1 Feb 2023

Wang Jingyuan, Xiu Joanne, Farrell Alex, Baca Yasmine, Arai Hiroyuki, Battaglin Francesca, Kawanishi Natsuko, Soni Shivani, Zhang Wu, Millstein Joshua, Shields Anthony F, Grothey Axel, Weinberg Benjamin A, Marshall John L, Lou Emil, Khushman Moh'd, Sohal Davendra P S, Hall Michael J, Liu Tianshu, Oberley Matthew, Spetzler David, Korn W Michael, Shen Lin, Lenz Heinz-Josef

Abstract excerpt

BACKGROUND: Genomic signatures contributing to high tumour mutational burden (TMB-H) independent from mismatch-repair deficiency (dMMR) or microsatellite instability-high (MSI-H) status are not well studied. We aimed to characterise molecular features of microsatellite stable (MSS) TMB-H gastrointestinal tumours. METHODS: Molecular alterations of 48 606 gastrointestinal tumours from Caris Life Sciences (CARIS)...

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PMID: 36681091
DOI: 10.1016/S1470-2045(22)00783-5
PMCID: PMC10599647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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