Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.

PLoS computational biology - 1 Jan 2012

Murail Samuel, Howard Rebecca J, Broemstrup Torben, Bertaccini Edward J, Harris R Adron, Trudell James R, Lindahl Erik

Abstract excerpt

Cys-loop receptors constitute a superfamily of pentameric ligand-gated ion channels (pLGICs), including receptors for acetylcholine, serotonin, glycine and γ-aminobutyric acid. Several bacterial homologues have been identified that are excellent models for understanding allosteric binding of alcohols and anesthetics in human Cys-loop receptors. Recently, we showed that a single point mutation on a prokaryotic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Chloride Channels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ethanol

Share to Lipid Bilayers

Share to Molecular Dynamics Simulation

Share to Phosphatidylcholines

Share to Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 23055913
DOI: 10.1371/journal.pcbi.1002710
PMCID: PMC3464191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.PMID 23055913Read ↗

A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation.Semantic proximity Read ↗

Pentameric ligand-gated ion channels exhibit distinct transmembrane domain archetypes for folding/expression and function.Semantic proximity Read ↗

A cationic lipid site at the outward transmembrane face of a pentameric ligand-gated ion channelSemantic proximity Read ↗

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation.Semantic proximity Read ↗

Ligand-induced motions in pentameric ligand-gated ion channels revealed by EPR spectroscopySemantic proximity Read ↗

Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.Semantic proximity Read ↗

Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.Semantic proximity Read ↗

Identification of a pre-active conformation of a pentameric channel receptor.Semantic proximity Read ↗

A Single phenylalanine residue in the main intracellular loop of α1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol.Semantic proximity Read ↗

Structural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation.Semantic proximity Read ↗

Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.Semantic proximity Read ↗

Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.