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Article

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation.

eLife - 30 Sept 2021

Lefebvre Solène N, Taly Antoine, Menny Anaïs, Medjebeur Karima, Corringer Pierre-Jean

Abstract excerpt

Pentameric ligand-gated ion channels (pLGICs) mediate chemical signaling through a succession of allosteric transitions that are yet not completely understood as intermediate states remain poorly characterized by structural approaches. In a previous study on the prototypic bacterial proton-gated channel GLIC, we generated several fluorescent sensors of the protein conformation that report a fast transition to a...

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Bacterial Proteins
Cyanobacteria
Escherichia coli
Ion Channel Gating
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Docking Simulation

Protein Conformation

Structure-Activity Relationship

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PMID: 34590583
DOI: 10.7554/eLife.60682
PMCID: PMC8504973

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