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A screen of plant-based natural products revealed that quercetin prevents amyloid-β uptake in astrocytes as well as resulting astrogliosis and synaptic dysfunction

2024-04-18

Abstract excerpt

<title>Abstract</title> <p>Two connected histopathological hallmarks of Alzheimer’s disease (AD) are chronic neuroinflammation and synaptic dysfunction. The accumulation of the most prevalent posttranslationally modified form of Aβ1–42, pyroglutamylated amyloid-β (Aβ3(pE)-42) in astrocytes is directly linked to glial activation and the release of proinflammatory cytokines that in turn contribute to early synaptic...

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Literature Corpus work: 5d198d07-1151-5508-94af-7f21a327729a
DOI: 10.21203/rs.3.rs-4155455/v1

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