Article

Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice

2019-12-30

Abstract excerpt

Numerous mutational studies have demonstrated that circadian clock proteins regulate behavior and metabolism. Nr1d1(Rev-erbα) is a key regulator of circadian gene expression and a pleiotropic regulator of skeletal muscle homeostasis and lipid metabolism. Loss of Rev-erbα expression induces muscular atrophy, high adiposity, and metabolic syndrome in mice. Here we show that, unlike knockout mice, Nr1d1 heterozygo...

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Literature Corpus work: 5cf5fced-cae3-5766-a49c-d2ff8bf4c55c
DOI: 10.1101/2019.12.30.890806

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