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Article

Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue.

Endocrinology - 1 Feb 2009

Narvaez Carmen J, Matthews Donald, Broun Emily, Chan Michelle, Welsh JoEllen

Abstract excerpt

Increased adiposity is a feature of aging in both mice and humans, but the molecular mechanisms underlying age-related changes in adipose tissue stores remain unclear. In previous studies, we noted that 18-month-old normocalcemic vitamin D receptor (VDR) knockout (VDRKO) mice exhibited atrophy of the mammary adipose compartment relative to wild-type (WT) littermates, suggesting a role for VDR in adiposity. Here...

Topics

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Adipose Tissue, White
Adiposity
Diet, Atherogenic
Dietary Fats
Eating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Uncoupling Protein 1

Vitamin D Deficiency

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Open in PubMed Open full text

Identifiers

PMID: 18845643
DOI: 10.1210/en.2008-1118
PMCID: PMC2646525

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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