Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice.

doi:10.1038/s44161-023-00223-z

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Article

Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice.

Nature cardiovascular research - 1 Mar 2023

Tham Yow Keat, Bernardo Bianca C, Claridge Bethany, Yildiz Gunes S, Woon Liesel Min-Linn, Bond Simon, Fang Haoyun, Ooi Jenny Y Y, Matsumoto Aya, Luo Jieting, Tai Celeste M K, Harmawan Claudia A, Kiriazis Helen, Donner Daniel G, Mellett Natalie A, Abel E Dale, Khan Sohaib A, De Souza David P, Doomun Sheik Nadeem Elahee, Liu Kevin, Xiang Ruidong, Singh Manika, Inouye Michael, Meikle Peter J, Weeks Kate L, Drew Brian G, Greening David W, McMullen Julie R

Abstract excerpt

Dysregulation of estrogen receptor alpha (ERα) has been linked with increased metabolic and cardiovascular disease risk. Here, we generate and characterize cardiomyocyte-specific ERα knockout (ERαHKO) mice to assess the role of ERα in the heart. The most striking phenotype was obesity in female ERαHKO but not male ERαHKO mice. Female ERαHKO mice showed cardiac dysfunction, mild glucose and insulin intolerance and...

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PMID: 39196021
DOI: 10.1038/s44161-023-00223-z

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