Relevance of Interferon Regulatory Factor-8 Expression in Myeloid–Tumor Interactions

Abstract excerpt

Perturbations in myelopoiesis are a common feature in solid tumor biology, reflecting the central premise that cancer is not only a localized affliction but also a systemic disease. Because the myeloid compartment is essential for the induction of adaptive immunity, these alterations in myeloid development contribute to the failure of the host to effectively manage tumor progression. These "dysfunctional" myeloid...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chemokine receptors and signaling
• Share to Cytokine Signaling Pathways and Interactions
• Share to Immune cells in cancer