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Article

Fast multiple-trait genome-wide association analysis for correlated longitudinal measurements.

Scientific reports - 23 Nov 2023

Abdel-Azim Gamal, Patel Parth, Li Shuwei, Guo Shicheng, Black Mary Helen

Abstract excerpt

Large-scale longitudinal biobank data can be leveraged to identify genetic variation contributing to human diseases progression and traits trajectories. While methods for genome-wide association studies (GWAS) of multiple correlated traits have been proposed, an efficient multiple-trait approach to model longitudinal phenotypes is not currently available. We developed GAMUT, a genome-wide association approach for...

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PMID: 37996550
DOI: 10.1038/s41598-023-47555-1
PMCID: PMC10667366

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