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Article

Genetic random effects model for family data with long-term survivors: analysis of diabetic nephropathy in type 1 diabetes.

Genetic epidemiology - 1 Nov 2007

Pitkäniemi Janne, Moltchanova Elena, Haapala Laura, Harjutsalo Valma, Tuomilehto Jaakko, Hakulinen Timo

Abstract excerpt

A shared and additive genetic variance component-long-term survivor (LTS) model for familial aggregation studies of complex diseases with variable age-at-onset phenotype and non-susceptible subjects in the study cohort is proposed. LTS has been used from the early 1970s, especially in epidemiological studies of cancer. The LTS model utilizes information on the age at onset (survival) distribution to make...

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PMID: 17487884
DOI: 10.1002/gepi.20234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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