Article

Distinct recognition of mutant huntingtin aggregates by autophagy receptor SQSTM1/p62 versus optineurin has differential effects on cell survival

2024-03-15

Abstract excerpt

<title>Abstract</title> <p>Huntington's disease (HD) is a neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the N-terminus of huntingtin (HTT). Mutant HTT (mHTT) undergoes misfolding and tends to aggregate, yet these aggregates are not effectively cleared by autophagy thus contributing to neurotoxicity in HD. The polyQ length of HTT in patients with HD varies from 40 to > 90; however, the p...

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Literature Corpus work: 5cb74ab8-892b-55b9-b129-9cb075a5b4a8
DOI: 10.21203/rs.3.rs-3998870/v1

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