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Article

A toxic mutant huntingtin species is resistant to selective autophagy.

Nature chemical biology - 1 Nov 2017

Fu Yuhua, Wu Peng, Pan Yuyin, Sun Xiaoli, Yang Huiya, Difiglia Marian, Lu Boxun

Abstract excerpt

Protein misfolding is a common theme in neurodegenerative disorders including Huntington's disease (HD). The HD-causing mutant huntingtin protein (mHTT) has an expanded polyglutamine (polyQ) stretch that may adopt multiple conformations, and the most toxic of these is the one recognized by antibody 3B5H10. Here we show that the 3B5H10-recognized mHTT species has a slower degradation rate due to its resistance to...

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PMID: 28869595
DOI: 10.1038/nchembio.2461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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