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Article

Neuronal cell line expressing full-length mutant huntingtin displays alteration of proteasome activity

2026-01-16

Abstract excerpt

Polyglutamine diseases are incurable genetic neurodegenerative disorders characterized by the accumulation of extended polyglutamine fragments-containing mutant proteins, which are prone to the formation of poorly soluble aggregates. The adequate cellular model is crucial in uncovering the pathological mechanisms responsible for neurotoxicity in HD, screening for therapeutic molecules and elucidation of the molecu...

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Literature Corpus work
60a1ef1c-fe1b-5b31-9443-a317e7d53661
DOI
10.64898/2026.01.15.699723
Open publication

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Neuronal cell line expressing full-length mutant huntingtin displays alteration of proteasome activityDOI 10.64898/2026.01.15.699723
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